Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China; Psychoradiology Research Unit of the Chinese Academy of Medical Sciences (2018RU011), West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Neurosci Biobehav Rev. 2021 Dec;131:1027-1036. doi: 10.1016/j.neubiorev.2021.10.017. Epub 2021 Oct 22.
Posttraumatic stress disorder (PTSD) is associated with dysfunction in large-scale brain functional networks, as revealed by resting-state functional connectivity studies. However, it remains unclear which networks have been most consistently affected and, more importantly, what role disease and trauma may play in the disrupted functional networks. We performed a systematic review of studies exploring network alterations using seed-based functional connectivity analysis, comparing individuals with PTSD to controls in general as well as trauma-exposed or nonexposed controls specifically, and quantitative meta-analysis was conducted when the number of studies was appropriately high. We found that hypoconnectivity within the default-mode network (DMN) as well as between the affective network (AN) and DMN were specifically associated with traumatic experience. Additionally, hyperconnectivity between the AN and somatomotor network (SMN) and between the DMN and SMN were specifically related to PTSD. Our results emphasize the effect of trauma itself on alterations in intrinsic brain networks and highlight disease-associated network alterations, which may help us better understand the neural mechanisms of trauma and PTSD.
创伤后应激障碍（PTSD）与静息态功能连接研究揭示的大脑功能网络的大范围功能障碍有关。然而，目前尚不清楚哪些网络受到的影响最一致，更重要的是，疾病和创伤在功能网络的破坏中可能扮演什么角色。我们使用基于种子的功能连接分析对研究网络改变进行了系统回顾，一般将 PTSD 患者与对照组进行比较，也专门将创伤暴露或未暴露的对照组进行比较，当研究数量足够多时，进行定量荟萃分析。我们发现，默认模式网络（DMN）内以及情感网络（AN）和 DMN 之间的连接不足与创伤经历有关。此外，AN 和躯体运动网络（SMN）之间以及 DMN 和 SMN 之间的过度连接与 PTSD 有关。我们的研究结果强调了创伤本身对内在脑网络改变的影响，并突出了与疾病相关的网络改变，这可能有助于我们更好地理解创伤和 PTSD 的神经机制。
