Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee.
Transplant Cell Ther. 2022 May;28(5):225-232. doi: 10.1016/j.jtct.2022.02.013. Epub 2022 Feb 22.
The Practice Guidelines Committee of the American Society for Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A completely new approach was taken with the goal of better serving clinical providers by publishing each standalone topic in the infectious disease series as a concise format of frequently asked questions (FAQ), tables, and figures. Adult and pediatric infectious disease and HCT content experts developed and then answered FAQs and finalized topics with harmonized recommendations that were made by assigning an A through E strength of recommendation paired with a level of supporting evidence graded I through III. This fifth guideline in the series focuses on Clostridioides difficile infection with FAQs that address the prevalence, incidence, clinical features, colonization versus infection, clinical complications, diagnostic considerations, pharmacological therapies for episodic or recurrent infection, and the roles of prophylactic antibiotics, probiotics, and fecal microbiota transplantation.
美国移植和细胞治疗学会的实践指南委员会与其移植传染病特别兴趣小组合作，更新了其 2009 年造血细胞移植（HCT）传染病指南的纲要式指南。采用了全新的方法，其目标是通过将传染病系列中的每个独立主题作为常见问题解答（FAQ）、表格和图表的简明格式出版，为临床医生提供更好的服务。成人和儿科传染病和 HCT 内容专家制定了常见问题解答，然后回答了这些问题，并通过为每个建议分配 A 至 E 的推荐强度以及 I 至 III 级的支持证据级别，最终确定了协调一致的建议。该系列的第五个指南重点介绍艰难梭菌感染，其常见问题解答涵盖了患病率、发病率、临床特征、定植与感染、临床并发症、诊断注意事项、发作性或复发性感染的药物治疗，以及预防性抗生素、益生菌和粪便微生物群移植的作用。
