Majumdar Anjali, Shah Mansi R, Park Jiyeon J, Narayanan Navaneeth, Kaye Keith S, Bhatt Pinki J
Division of Allergy and Infectious Disease, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Division of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
Antibiotics (Basel). 2023 Mar 16;12(3):592. doi: 10.3390/antibiotics12030592.
Antimicrobial stewardship programs play a critical role in optimizing the use of antimicrobials against pathogens in the era of growing multi-drug resistance. However, implementation of antimicrobial stewardship programs among the hematopoietic stem cell transplant and oncology populations has posed challenges due to multiple risk factors in the host populations and the infections that affect them. The consideration of underlying immunosuppression and a higher risk for poor outcomes have shaped therapeutic decisions for these patients. In this multidisciplinary perspective piece, we provide a summary of the current landscape of antimicrobial stewardship, unique challenges, and opportunities for unmet needs in these patient populations.
在多重耐药性不断增加的时代，抗菌药物管理计划在优化抗病原体抗菌药物的使用方面发挥着关键作用。然而，由于宿主人群中的多种风险因素以及影响他们的感染，在造血干细胞移植和肿瘤患者群体中实施抗菌药物管理计划面临挑战。对潜在免疫抑制和不良预后较高风险的考虑影响了这些患者的治疗决策。在这篇多学科观点文章中，我们总结了抗菌药物管理的当前情况、独特挑战以及这些患者群体中未满足需求的机遇。
