Division of Plastic and Reconstructive Surgery, Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.
Cells. 2022 Feb 15;11(4):672. doi: 10.3390/cells11040672.
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA and chromatin are powerful regulators of genome architecture and gene expression, and they play a crucial role in mediating the induction and maintenance of senescence. This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
衰老是一种复杂的细胞应激反应，它会消除细胞的增殖能力，并产生一种独特的分泌模式，这种模式与机体衰老和与年龄相关的疾病有关。细胞如何过渡到衰老状态是多因素的，通常需要多个基因的转录调控。DNA 和染色质的表观遗传改变是基因组结构和基因表达的有力调节剂，它们在介导衰老的诱导和维持中起着至关重要的作用。本文综述了建立和维持细胞衰老的染色质、DNA 甲基化和组蛋白改变，以及衰老相关分泌表型 (SASP) 的特定表观遗传调控。
