Bures J, Horák V, Fixa B, Komárková O, Zaydlar K, Lonský V, Masurka V
Neoplasma. 1986;33(2):233-7.
Colicins, bacteriocins of Escherichia coli and related bacteria of Enterobacteriaceae family, form a very heterogeneous group of antibiotically active substances of proteinaceous material. Antitumorous effect of colicins have also been demonstrated experimentally. The large bowel has been found to be a site of their native action. Therefore, our work has been aimed at investigating colicinogenicity in patients with colorectal carcinoma. From a total number of 77 patients with colorectal carcinoma, colicinogenic Escherichia coli was found in 32 persons (41.6%), whereas from a total of 160 control clinically healthy persons, colicinogenic Escherichia coli was found in 102 persons (63.8%). The difference is statistically significant (p less than 0.05). The absence of colicinogenic Escherichia coli may be one of the factors contributing to the origin and development of colorectal carcinoma in some of the patients studied. Studies of patients with adenomatous polyps, members of colon cancer families, and large prospective studies of the general population will be necessary to prove this hypothesis.
大肠杆菌素是大肠杆菌及肠杆菌科相关细菌产生的细菌素，它们构成了一组非常异质的蛋白质类抗生素活性物质。实验也已证明大肠杆菌素具有抗肿瘤作用。已发现大肠是它们的天然作用部位。因此，我们的工作旨在研究结直肠癌患者的产大肠杆菌素情况。在总共77例结直肠癌患者中，32人（41.6%）检测出产大肠杆菌素的大肠杆菌，而在总共160例临床健康对照者中，102人（63.8%）检测出产大肠杆菌素的大肠杆菌。差异具有统计学意义（p小于0.05）。在所研究的部分患者中，产大肠杆菌素的大肠杆菌缺失可能是导致结直肠癌发生和发展的因素之一。有必要对腺瘤性息肉患者、结肠癌家族成员以及对普通人群进行大规模前瞻性研究来证实这一假设。
