Pisano Calogera, Benedetto Umberto, Ruvolo Giovanni, Balistreri Carmela Rita
Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy.
Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK.
Antioxidants (Basel). 2022 Jan 18;11(2):182. doi: 10.3390/antiox11020182.
Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments.
主动脉疾病，如升主动脉瘤（AsAA），是复杂的病理状况，目前被定义为具有强烈遗传易感性的炎症性疾病。它们难以处理，是隐匿性和无症状的病理状况，其诊断仅基于影像学数据。迄今为止，尚无诊断和预后生物标志物或结局标志物。因此，识别它们势在必行。当然，深入了解其发病机制中涉及的机制和途径可能有助于此类研究。最近，氧化应激（OS）在主动脉疾病病理生理学中的关键作用已显现出来。在此，我们通过揭示一些作为潜在生物标志物的OS途径、其潜在局限性、潜在解决方案和方法以及一些潜在治疗方法来描述和讨论这些方面。
