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过氧化物酶体增殖物激活受体γ（PPAR-γ）激动剂吡格列酮对改善庆大霉素诱导的成年雄性白化大鼠睾丸损伤中的氧化应激、生殖细胞凋亡和炎症的预防及改善作用

Prophylactic and Ameliorative Effects of PPAR-γ Agonist Pioglitazone in Improving Oxidative Stress, Germ Cell Apoptosis and Inflammation in Gentamycin-Induced Testicular Damage in Adult Male Albino Rats.

作者信息

El-Sayed Karima, Ali Dina A, Maher Shymaa Ahmed, Ghareeb Dalia, Selim Samy, Albogami Sarah, Fayad Eman, Kolieb Eman

机构信息

Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.

Clinical Pharmacology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.

出版信息

Antioxidants (Basel). 2022 Jan 19;11(2):191. doi: 10.3390/antiox11020191.

DOI:10.3390/antiox11020191
PMID:35204074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8868260/
Abstract

Peroxisome proliferator-activated receptor gamma (PPAR-γ) is ubiquitously expressed in testicular tissue and plays a crucial role in regulating various physiological processes. Pioglitazone (PIO) is one of the PPAR-γ agonists, having anti-oxidant and anti-inflammatory effects. Patients on gentamycin treatment may undergo serious side effects such as testicular damage. To the best of our knowledge, this was the first study to investigate the possible protective anti-inflammatory and anti-apoptotic effects of PIO on gentamycin-induced testicular damage. Fifty adult male Wistar albino rats included in the study as the control group (CTL) received normal saline; a gentamycin-induced testicular damage group (GM) received gentamycin (100 mg/kg); PIO5, PIO10, PIO20 groups received PIO at a dose of 5, 10, and 20 mg/ kg, respectively, for 21 days, and gentamycin was started at day 15 of the experiment for 6 days. The parameters of spermatozoa and histopathological alterations in the testes were significantly improved in the PIO20 group. Moreover, MDA levels, inflammatory mediators, and apoptotic Bax expression were decreased. The activity of glutathione peroxidase, catalase, total antioxidant capacity, and anti-apoptotic Bcl-2 genes expression were increased. It was concluded that PIO20 could protect against gentamycin-induced testicular damage in Wistar rats through its anti-oxidant, anti-inflammatory, and antiapoptotic effects.

摘要

过氧化物酶体增殖物激活受体γ（PPAR-γ）在睾丸组织中广泛表达，在调节各种生理过程中起关键作用。吡格列酮（PIO）是PPAR-γ激动剂之一，具有抗氧化和抗炎作用。接受庆大霉素治疗的患者可能会出现严重的副作用，如睾丸损伤。据我们所知，这是第一项研究吡格列酮对庆大霉素诱导的睾丸损伤可能具有的保护性抗炎和抗凋亡作用的研究。该研究中，50只成年雄性Wistar白化大鼠作为对照组（CTL）接受生理盐水；庆大霉素诱导的睾丸损伤组（GM）接受庆大霉素（100mg/kg）；PIO5、PIO10、PIO20组分别接受剂量为5、10和20mg/kg的PIO，持续21天，庆大霉素在实验第15天开始使用，持续6天。PIO20组的精子参数和睾丸组织病理学改变得到显著改善。此外，丙二醛水平、炎症介质和凋亡相关蛋白Bax表达降低。谷胱甘肽过氧化物酶、过氧化氢酶的活性、总抗氧化能力以及抗凋亡蛋白Bcl-2基因表达增加。得出的结论是，PIO20可通过其抗氧化、抗炎和抗凋亡作用保护Wistar大鼠免受庆大霉素诱导的睾丸损伤。

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