Woo Ha Young, Kim Sang Kyum
Department of Pathology, National Cancer Center, Goyang 10408, Korea.
Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul 02447, Korea.
Diagnostics (Basel). 2022 Feb 2;12(2):383. doi: 10.3390/diagnostics12020383.
Nevus comedonicus (NC) is a rare hamartoma of the pilosebaceous unit origin. The association with extracutaneous abnormalities defines NC syndrome (NCS). Fewer than 50 cases of NCS have been reported in the English literature. A 31-year-old woman presented with grouped and linear comedonal papules present from birth and located on the left buttock along Blaschko's lines. She had a history of pediatric mood disorder combined with attention-deficit hyperactivity disorder (ADHD) from 5 years of age and was recently diagnosed with sinus bradycardia. Her skin lesion was surgically removed and microscopic findings revealed the aggregation of dilated follicular infundibula filled with prominent laminated keratin plugs, a characteristic finding of NC. This is the first report presenting NCS associated with mood disorder and ADHD. Psychiatric symptoms may represent systemic manifestation of NCS.
粉刺痣（NC）是一种罕见的起源于毛囊皮脂腺单位的错构瘤。与皮肤外异常相关可定义为粉刺痣综合征（NCS）。英文文献中报道的NCS病例少于50例。一名31岁女性自出生起就出现成群的、沿Blaschko线分布于左臀部的线性粉刺样丘疹。她有小儿情绪障碍病史，5岁起合并注意力缺陷多动障碍（ADHD），最近被诊断为窦性心动过缓。她的皮肤病变通过手术切除，显微镜检查结果显示扩张的毛囊漏斗聚集，充满突出的层状角质栓，这是NC的特征性表现。这是首例报道NCS与情绪障碍和ADHD相关的病例。精神症状可能代表NCS的全身表现。
