Bcl-2 家族成员与线粒体导入机制：通向死亡之路。
Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death.
机构信息
CRCINA, Inserm, Université de Nantes, Université d'Angers, 44000 Nantes, France.
LaBCT, Institut de Cancérologie de L'Ouest, 44800 Saint Herblain, France.
出版信息
Biomolecules. 2022 Jan 19;12(2):162. doi: 10.3390/biom12020162.
The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis.
Bcl-2 家族成员在线粒体膜外膜（MOM）的定位是细胞凋亡实施的关键步骤。我们回顾了证据表明，线粒体输入机制（外膜转位酶（TOM）和分选与装配机器（SAM））的组件在 Bcl-2 家族成员的线粒体定位中的作用，以及这些机制如何调节在静息细胞和凋亡细胞中促凋亡和抗凋亡蛋白的功能。
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