细菌外膜的蛋白输入和输出。
Protein import and export across the bacterial outer membrane.
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
出版信息
Curr Opin Struct Biol. 2021 Aug;69:55-62. doi: 10.1016/j.sbi.2021.03.007. Epub 2021 Apr 23.
The bacterial outer membrane forms an impermeable barrier to the environment, but a wide variety of substances must cross it without compromising the membrane. Perhaps, the most fascinating transport phenomenon is the import and export of very large protein toxins using relatively small β-barrel proteins residing in the outer membrane. Progress has been made on three systems in recent years that shed light on this process. In this review, we summarize bacteriocin (toxin) import using TonB-dependent transporters and protein secretion by autotransporters and two partner secretion systems.
细菌外膜形成了一个对环境不可渗透的屏障，但仍有大量物质必须穿过它而不损害膜的完整性。也许，最吸引人的运输现象是使用相对较小的β-桶状蛋白在将非常大的蛋白毒素导入和导出细胞，而这些蛋白位于外膜中。近年来，在三个系统方面的进展揭示了这个过程。在这篇综述中，我们总结了使用 TonB 依赖性转运蛋白的细菌素（毒素）导入和由自转运蛋白和两个伴侣分泌系统介导的蛋白分泌。
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