Section of Vascular Surgery, Department of Surgery, University of Michigan, 5364 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
Biomolecules. 2022 Jan 21;12(2):172. doi: 10.3390/biom12020172.
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity and mortality in the setting of acute rupture. Recently, advances in surgical and endovascular repair of AAA have been achieved; however, pharmaceutical therapies to prevent AAA expansion and rupture remain lacking. This highlights an ongoing need to improve the understanding the pathological mechanisms that initiate formation, maintain growth, and promote rupture of AAA. Over the past decade, epigenetic modifications, such as DNA methylation, posttranslational histone modifications, and non-coding RNA, have emerged as important regulators of cellular function. Accumulating studies reveal the importance of epigenetic enzymes in the dynamic regulation of key signaling pathways that alter cellular phenotypes and have emerged as major intracellular players in a wide range of biological processes. In this review, we discuss the roles and implications of epigenetic modifications in AAA animal models and their relevance to human AAA pathology.
腹主动脉瘤（AAA）是一种危及生命的疾病，在急性破裂的情况下，其发病率和死亡率都很高。近年来，AAA 的外科和血管内修复技术取得了进展；然而，预防 AAA 扩张和破裂的药物治疗仍然缺乏。这突出表明，人们需要不断提高对引发 AAA 形成、维持生长和促进破裂的病理机制的认识。在过去的十年中，表观遗传修饰，如 DNA 甲基化、翻译后组蛋白修饰和非编码 RNA，已成为细胞功能的重要调节剂。越来越多的研究揭示了表观遗传酶在改变细胞表型的关键信号通路的动态调节中的重要作用，并成为广泛的生物学过程中的主要细胞内参与者。在这篇综述中，我们讨论了表观遗传修饰在 AAA 动物模型中的作用和意义及其与人类 AAA 病理学的相关性。
