Mohamed Amany Abdel-Rahman, Bohy Khlood M El, Moustafa Gihan G, Mohammed Hesham H, Metwally Mohamed M M, Mohammed Heba El Desoukey, Nassan Mohamed A, Saber Taghred M
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 4511, Egypt.
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.
Biology (Basel). 2022 Feb 10;11(2):279. doi: 10.3390/biology11020279.
: This study provides a model for studying the mechanism(s) responsible for the nervous tissue damage and misfunctioning that occurred due to oral nicotine exposure, considered a stress factor, during the presence of Ehrlich ascites carcinoma bearing in the mouse model (EAC). The mitigating role of ) against nicotine-induced brain damage was evaluated. : Eighty Swiss female mice were classified into four groups, these were the control, the group, the nicotine group(100 µg/kg), and the combination group. Oxidant/antioxidant status, proinflammatory cytokines levels, DNA damage, quantitative microscopical lesions, and Caspase 3, Bcl-2 proteins were assessed in the current study. Levels of dopamine (DA) and gamma-aminobutyric acid (GABA) were also evaluated. : Nicotine was found to cause pronounced neurobehavioral alterations, increase the mortalities oxidative stress DNA damage, and augment the inflammatory response in brain tissue alongside the microstructural alteration. The administration of with nicotine in EAC-bearing mice rescued the detrimental effects of nicotine. : aids in reducing the harmful effects of nicotine and returns the conditions caused by nicotine to near-control levels. Thus, we are in favor of giving it to cancer patients who are taking daily dosages of nicotine even by smoking cigarettes or being exposed to second-hand smoke.
本研究提供了一个模型，用于研究在小鼠艾氏腹水癌（EAC）模型中，由于口服尼古丁暴露（被视为一种应激因素）而导致神经组织损伤和功能失调的机制。评估了（此处原文缺失具体物质）对尼古丁诱导的脑损伤的减轻作用。80只瑞士雌性小鼠被分为四组，即对照组、（此处原文缺失具体物质）组、尼古丁组（100μg/kg）和联合组。在本研究中评估了氧化/抗氧化状态、促炎细胞因子水平、DNA损伤、定量显微镜下病变以及半胱天冬酶3、Bcl-2蛋白。还评估了多巴胺（DA）和γ-氨基丁酸（GABA）的水平。发现尼古丁会导致明显的神经行为改变，增加死亡率、氧化应激、DNA损伤，并加剧脑组织中的炎症反应以及微观结构改变。在携带EAC的小鼠中，将（此处原文缺失具体物质）与尼古丁一起给药可挽救尼古丁的有害影响。（此处原文缺失具体物质）有助于降低尼古丁的有害影响，并使由尼古丁引起的状况恢复到接近对照水平。因此，我们赞成将其给予每天摄入尼古丁（即使是通过吸烟或接触二手烟）的癌症患者。
