Shabat Sheer, Meiner Zeev, Tsenter Jeanna, Schwartz Isabella, Portnoy Sigal
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91905, Israel.
Department of Physical Medicine and Rehabilitation, Hadassah Medical Center, Jerusalem 9765418, Israel.
Biology (Basel). 2022 Feb 10;11(2):277. doi: 10.3390/biology11020277.
Patients with Coronavirus-2019 (COVID-19) manifest many neuromuscular complications. We evaluated the correlations between electromyography and nerve conduction measurements among COVID-19 patients and the severity of the initial infection, as well as the rehabilitation outcomes, and searched for the factors which best predict the rehabilitation outcomes. A total of 19 COVID-19 patients (16 men; mean ± SD age 59.1 ± 10.4), with WHO clinical progression scale of 6.8 ± 2.3, received rehabilitation for 3.9 ± 2.5 months. The Functional Independence Measure (FIM), the 10 m walk test, the 6 minute walk test, and grip force were collected before and after the rehabilitation period. Motor Nerve Conduction (MNC), Sensory Nerve Conduction (SNC) and electromyographic abnormalities were measured. All of the MNC measures of the median nerve correlated with the WHO clinical progression scale and duration of acute hospitalization. The MNC and SNC measures correlated with the rehabilitation duration and with FIM at discharge. The MNC distal latency of the median and the peroneal nerves and the MNC velocity of the median and tibial nerves predicted 91.6% of the variance of the motor FIM at discharge. We conclude that nerve conduction measurements, especially in COVID-19 patients with severe illness, are important in order to predict prognosis and rehabilitation outcomes.
2019冠状病毒病（COVID-19）患者表现出许多神经肌肉并发症。我们评估了COVID-19患者肌电图和神经传导测量结果与初始感染严重程度以及康复结局之间的相关性，并寻找最能预测康复结局的因素。共有19例COVID-19患者（16例男性；平均±标准差年龄59.1±10.4岁），世界卫生组织临床进展量表评分为6.8±2.3，接受了3.9±2.5个月的康复治疗。在康复期前后收集了功能独立性测量（FIM）、10米步行试验、6分钟步行试验和握力数据。测量了运动神经传导（MNC）、感觉神经传导（SNC）和肌电图异常情况。正中神经的所有MNC测量值均与世界卫生组织临床进展量表及急性住院时间相关。MNC和SNC测量值与康复时间及出院时的FIM相关。正中神经和腓总神经的MNC远端潜伏期以及正中神经和胫神经的MNC速度可预测出院时运动FIM变异的91.6%。我们得出结论，神经传导测量，尤其是在重症COVID-19患者中，对于预测预后和康复结局很重要。
