Cicione Antonio, Brassetti Aldo, Lombardo Riccardo, Franco Antonio, Turchi Beatrice, D'Annunzio Simone, Nacchia Antonio, Tubaro Andrea, Simone Giuseppe, De Nunzio Cosimo
Department of Urology, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy.
Department of Urology, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Cancers (Basel). 2022 Feb 14;14(4):936. doi: 10.3390/cancers14040936.
As metabolic syndrome (MetS) and a sedentary lifestyle have been associated with an increased risk of developing both prostate cancer (PCa) and cardiovascular diseases (CVDs), the 2 conditions may share a common etiology. We aimed at investigating the association between CVDs and PCa. A retrospective analysis was performed. Our dataset on patients undergone systematic prostate biopsy was searched for histopathologic and clinical data. The physical activity (PA) scale for the elderly (PASE) was collected. Coronary heart diseases (CHDs) were recorded. Prognostic Grade Group ≥3 tumors were defined as high-grade (HG). The association between MetS, PA, CHDs and PCa was assessed using logistic regression analyses. Data on 955 patients were collected; 209 (22%) presented with MetS, 79 (8%) with CHDs. PCa was diagnosed in 395 (41.3%) men and 60% ( = 238) presented with an high-grade tumor. CHDs were more common among PCa-patients (9.4% vs. 7.5%; = 0.302) but the difference was not statistically significant. No difference was observed between low- and high-grade subgroups (9.5% vs. 9.2%; = 0.874). PASE independently predicted PCa diagnosis (OR: 0.287; = 0.001) and HG-PCa (OR: 0.165; = 0.001). MetS was an independent predictor of HG-PCa only (OR: 1.50; 95% CI: 1.100-2.560; = 0.023). CHDs were not associated with tumor diagnosis and aggressiveness.
由于代谢综合征（MetS）和久坐不动的生活方式与患前列腺癌（PCa）和心血管疾病（CVDs）的风险增加有关，这两种疾病可能有共同的病因。我们旨在研究心血管疾病与前列腺癌之间的关联。进行了一项回顾性分析。在我们关于接受系统性前列腺活检的患者的数据集中搜索组织病理学和临床数据。收集了老年人身体活动（PA）量表（PASE）。记录冠心病（CHD）情况。预后分级组≥3的肿瘤被定义为高级别（HG）。使用逻辑回归分析评估MetS、PA、CHD与PCa之间的关联。收集了955例患者的数据；209例（22%）患有MetS，79例（8%）患有CHD。395例（41.3%）男性被诊断为PCa，60%（=238例）为高级别肿瘤。CHD在PCa患者中更常见（9.4%对7.5%；=0.302），但差异无统计学意义。低级别和高级别亚组之间未观察到差异（9.5%对9.2%；=0.874）。PASE独立预测PCa诊断（OR：0.287；=0.001）和HG-PCa（OR：0.165；=0.001）。MetS仅是HG-PCa的独立预测因素（OR：1.50；95%CI：1.100-2.560；=0.023）。CHD与肿瘤诊断和侵袭性无关。
