Si E C, Bryant H U, Yim G K
Pharmacol Biochem Behav. 1986 Apr;24(4):899-903. doi: 10.1016/0091-3057(86)90434-x.
The present study was initiated to clarify the involvement of endogenous opioids in insulin-induced feeding. Naloxone (3 mg/kg) was injected in male Sprague Dawley rats every hour for 2 hours after insulin injection (10 U/kg). Only the first hour food intake was depressed (68% reduction). When naloxone was given only 1 hour after insulin administration, depression of food intake was not noted. When food was withheld for 2 hours after insulin injection, both naloxone and its long acting congener, naltrexone (3 mg/kg) were able to depress only the first hour feeding subsequent to food presentation. These data suggest that insulin-induced feeding can be divided into two pharmacologically distinct phases: the early phase being naloxone-sensitive while the late phase is naloxone-insensitive. Furthermore, the early phase begins with the presentation of food and not with the administration of insulin.
本研究旨在阐明内源性阿片类物质在胰岛素诱导进食中的作用。在注射胰岛素（10 U/kg）后，每小时给雄性斯普拉格-道利大鼠注射纳洛酮（3 mg/kg），持续2小时。仅第一小时的食物摄入量受到抑制（减少68%）。当在胰岛素给药后仅1小时给予纳洛酮时，未观察到食物摄入量的抑制。在注射胰岛素后禁食2小时，纳洛酮及其长效同类物纳曲酮（3 mg/kg）均仅能抑制食物呈现后的第一小时进食。这些数据表明，胰岛素诱导的进食可分为两个药理学上不同的阶段：早期阶段对纳洛酮敏感，而晚期阶段对纳洛酮不敏感。此外，早期阶段始于食物的呈现，而非胰岛素的给药。
