McCoy D F, Roszman T L, Miller J S, Kelly K S, Titus M J
Physiol Behav. 1986;36(4):731-6. doi: 10.1016/0031-9384(86)90361-6.
Three experiments were conducted in which an illness-inducing immunosuppressant, cyclophosphamide (an unconditioned stimulus, US) was associated with a previously presented saccharin solution conditioned stimulus (CS). In each experiment, reexposure to the CS produced a conditioned suppression of the plaque-forming-cell response in the experimental groups. Experiment I demonstrated this result with Fisher 344 rats. Experiment II replicated the effect with Balb/c mice. In Experiment III conditioned immunosuppression was demonstrated when mice received CS-US delays as long as 6 hours. No evidence of a delay gradient was present in either the behavioral or the immunologic data. These parallel findings offer no support for the idea of a dissociation between the taste aversion and conditioned immunosuppression processes.
进行了三项实验，其中将一种可诱发疾病的免疫抑制剂环磷酰胺（一种无条件刺激物，US）与先前呈现的糖精溶液条件刺激物（CS）联系起来。在每个实验中，重新接触CS会在实验组中产生对斑块形成细胞反应的条件性抑制。实验I在Fisher 344大鼠中证明了这一结果。实验II用Balb/c小鼠重复了这一效应。在实验III中，当小鼠接受长达6小时的CS-US延迟时，证明了条件性免疫抑制。行为学或免疫学数据中均未出现延迟梯度的证据。这些平行的发现不支持味觉厌恶和条件性免疫抑制过程之间存在分离的观点。
