Institute for Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China.
Int J Environ Res Public Health. 2022 Feb 13;19(4):2096. doi: 10.3390/ijerph19042096.
The prevalence of metabolic-associated fatty liver disease (MAFLD) is rarely reported in Beijing. The goal of this study was to estimate the prevalence and risk factors of MAFLD among Beijing adults aged ≥25 years old. A cross-sectional, community-based survey with multistage stratified cluster sampling was used. Demographic, transient elastography (TE), biochemical and blood examination information was collected in all the subjects in this study. The prevalence of MAFLD was 32.40% (23,832/73,566). Risk factors independently associated with MAFLD included male gender (OR = 1.47, 95%CI, 1.43-1.52), urban residence (OR = 1.06, 95% CI, 1.02-1.10), older age (30-39 years: OR = 1.29; 40-49 years: OR = 1.43; 50-59 years: OR = 1.09; ≥60 years: OR = 1.52) and lower education (middle school: OR = 2.03; high school: OR = 1.89; undergraduate: OR = 1.69). MAFLD was more common in females than in males after 50 years of age. Lean/normal weight MAFLD patients account for approximately 3.04% (724/23,832) of MAFLD. Compared to non-MAFLD subjects, the lean/normal MAFLD patients had a higher prevalence of hypertension and diabetes, and had a higher degree of hepatic steatosis and liver function enzymology parameters (all < 0.001). MAFLD was highly prevalent among the general population aged ≥25 years old in Beijing. MAFLD was closely associated with male gender, older age, lower education and urban residence. Even lean/normal-weight people were under risk of MAFLD.
北京地区代谢相关性脂肪性肝病（MAFLD）的流行情况鲜有报道。本研究旨在评估北京≥25 岁成年人 MAFLD 的患病率及其相关危险因素。采用多阶段分层整群抽样的方法进行横断面社区调查。本研究对所有研究对象进行了人口统计学、瞬时弹性成像（TE）、生化和血液检查信息采集。MAFLD 的患病率为 32.40%（23,832/73,566）。与 MAFLD 独立相关的危险因素包括男性（OR=1.47，95%CI，1.43-1.52）、城市居住（OR=1.06，95%CI，1.02-1.10）、年龄较大（30-39 岁：OR=1.29；40-49 岁：OR=1.43；50-59 岁：OR=1.09；≥60 岁：OR=1.52）和较低的教育程度（中学：OR=2.03；高中：OR=1.89；本科：OR=1.69）。50 岁以后，女性 MAFLD 的发病率高于男性。瘦/正常体重 MAFLD 患者占 MAFLD 的比例约为 3.04%（724/23,832）。与非 MAFLD 患者相比，瘦/正常体重 MAFLD 患者高血压和糖尿病的患病率更高，且肝脂肪变性和肝功能酶学参数的程度更高（均<0.001）。北京≥25 岁一般人群中 MAFLD 的患病率较高。MAFLD 与男性、年龄较大、教育程度较低和城市居住密切相关。即使是瘦/正常体重人群也有患 MAFLD 的风险。
