Clinic of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, M. Pirogow's Teaching Hospital, Wilenska 37 St., 94-029 Lodz, Poland.
Int J Environ Res Public Health. 2022 Feb 17;19(4):2294. doi: 10.3390/ijerph19042294.
Adenomyosis is a common benign gynecological condition, defined as an extension of endometrial tissue into the myometrium. Some studies suggest that adenomyosis could be a favorable prediction factor associated with survival outcomes in endometrial cancer. The aim of our systematic review was to investigate the current knowledge regarding adenomyosis and a possible molecular mechanism of carcinogenesis in adenomyotic lesions. In addition, the long-term prognosis for patients with endometrial cancer and coexisting adenomyosis (and endometriosis) was a key point of the research. The current literature was reviewed by searching PubMed, using the following phrases: "adenomyosis and endometrial cancer" and "malignant transformation of adenomyosis". According to the literature, genetic mutations, epigenetic changes, and inactivation of specific tumor suppressor genes in adenomyosis are still poorly understood. Data regarding the influence of adenomyosis on survival outcomes in endometrial cancer seem to be contradictory and require further clinical and molecular investigation.
子宫腺肌病是一种常见的良性妇科疾病，定义为子宫内膜组织延伸到子宫肌层。一些研究表明，子宫腺肌病可能是子宫内膜癌生存结果的有利预测因素。我们的系统评价旨在研究目前关于子宫腺肌病的知识，以及子宫腺肌病病变中可能的致癌分子机制。此外，患有子宫内膜癌和并存的子宫腺肌病（和子宫内膜异位症）患者的长期预后是研究的一个关键点。通过在 PubMed 上搜索以下短语来回顾当前的文献：“adenomyosis and endometrial cancer”和“malignant transformation of adenomyosis”。根据文献，子宫腺肌病中的遗传突变、表观遗传改变和特定肿瘤抑制基因失活仍然知之甚少。关于子宫腺肌病对子宫内膜癌生存结果影响的数据似乎相互矛盾，需要进一步的临床和分子研究。
