Ovchinnikova E A, Mel'nik E G
Zh Mikrobiol Epidemiol Immunobiol. 1978 May(5):36-40.
The authors present the results of study of the virulence of shigellae isolated from carriers and patients suffering from acute dysentery, on a continuous culture of E1 and Hep-2 cells. The virulence of shigellae isolated from carriers displayed no significant difference from the virulence of shigellae isolated from patients with a mild and moderately severe forms of dysentery. In the patient's organism shigellae were capable of retaining the initial virulence for a long time, despite the treatment and the influence of the macroorganism's protective factors. The authors believe that this was connected with the capacity of Shigellae to parasitic life in the cells of human intestinal epithelium, and, apparently, played a definite role in the formation of carrier state.
作者介绍了从携带者及急性痢疾患者分离出的志贺氏菌在E1和Hep - 2细胞连续培养中的毒力研究结果。从携带者分离出的志贺氏菌毒力与从轻度和中度严重痢疾患者分离出的志贺氏菌毒力无显著差异。在患者机体中，尽管经过治疗且受到机体保护因子的影响，志贺氏菌仍能长时间保持初始毒力。作者认为，这与志贺氏菌在人肠道上皮细胞中寄生生活的能力有关，显然，在带菌状态的形成中起了一定作用。
