Jiménez E, Narváez J A, Montiel M, Ruiz M, Morell M
Rev Esp Fisiol. 1986 Mar;42(1):45-50.
The changes occurring in several components of the rat renin-angiotensin system (RAS) were studied for the brief postnatal period, between the fourth and tenth week of life. The parameters were: plasma renin activity (PRA), plasma renin concentration (PRC), plasma renin substrate (PRS) and the plasma angiotensin II concentration (AII). A gradual decrease in PRA with age was noticed. Between the fourth and the eighth weeks of life, this was attributed to a corresponding decline in both PRC and PRS. However, between the eighth and tenth weeks, no changes in PRA could be detected, but PRC and PRS increased, perhaps as a consequence of the changes in renal function and the AII increase observed. In this second period, simultaneously with the RAS changes described, there was reduced sodium chloride excretion as the glomerular filtration rate (GFR) stabilized. The data presented suggest that this postnatal period is critical, in rats, for the maturation of the RAS component control mechanisms; they appear to be closely related to the development of the renal function.
在出生后第四至第十周这一短暂时期，对大鼠肾素 - 血管紧张素系统（RAS）的几个组成部分发生的变化进行了研究。研究参数包括：血浆肾素活性（PRA）、血浆肾素浓度（PRC）、血浆肾素底物（PRS）和血浆血管紧张素II浓度（AII）。发现PRA随年龄逐渐降低。在出生后第四至第八周，这归因于PRC和PRS相应下降。然而，在第八至第十周，未检测到PRA有变化，但PRC和PRS增加，这可能是肾功能变化以及观察到的AII增加的结果。在这第二个时期，与上述RAS变化同时，随着肾小球滤过率（GFR）稳定，氯化钠排泄减少。所呈现的数据表明，在大鼠中，这个出生后时期对于RAS组成部分控制机制的成熟至关重要；它们似乎与肾功能的发展密切相关。
