Jiménez E, Montiel M, Narváez J A, Morell M
Rev Esp Fisiol. 1982 Mar;38(1):35-40.
The basal levels of angiotensin I (A. I), plasma renin activity (PRA), plasma renin substrate (PRS) and plasma renin concentration (PRC) were estimated in hyperthyroid rats before and after propranolol treatment. Serum levels of triiodothyronine (T3), thyroxine (T4), angiotensin I both basal and generated by incubation of plasma samples were measured by radioimmunoassay, while, PRC and PRS were evaluated by triiodothyronine or thyroxine treatment induced a decrease in PRS and an increase in PRC whereas triiodothyronine alone produced an increase in the basal levels of angiotensin I and PRA. The propranolol in euthyroid animals not only decreased the basal levels of angiotensin I and PRA, but also prevented the PRC increase in hyperthyroid rats, while restoring at the same time the basal levels of angiotensin I and PRA.
在给予普萘洛尔治疗前后，对甲状腺功能亢进大鼠的血管紧张素I（A.I）基础水平、血浆肾素活性（PRA）、血浆肾素底物（PRS）和血浆肾素浓度（PRC）进行了评估。采用放射免疫分析法测定血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、基础血管紧张素I水平以及血浆样本孵育产生的血管紧张素I水平，而PRC和PRS则通过三碘甲状腺原氨酸或甲状腺素治疗诱导PRS降低和PRC升高来评估，而单独使用三碘甲状腺原氨酸则使血管紧张素I和PRA的基础水平升高。在甲状腺功能正常的动物中，普萘洛尔不仅降低了血管紧张素I和PRA的基础水平，还阻止了甲状腺功能亢进大鼠PRC的升高，同时恢复了血管紧张素I和PRA的基础水平。
