Udzik Jakub, Jakubowski Paweł, Niekrasz Małgorzata, Barczyszyn Adrian, Parczewski Miłosz
Department of Physiology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Neurosurgery and Neurotraumatology, Samodzielny Publiczny Wojewódzki Szpital Zespolony, Arkońska 4, 71-455 Szczecin, Poland.
J Clin Med. 2022 Feb 13;11(4):981. doi: 10.3390/jcm11040981.
Neurological manifestations of the SARS-CoV-2 infection are present in up to 80% of the affected patients. While the majority of them is benign, in certain patients, viral replication in the central nervous system results in a severe disruption in cognitive function as well as basic life functions. In this case series, the authors present a detailed description of the three SARS-CoV-2 infection cases, which were all complicated by severe encephalopathy. Consecutive neurological status changes were described for each patient with detailed imaging and clinical sequelae. In the discussion, the authors highlight similarities in the course of the disease in presented patients, as well as common features in test results. An effective causal treatment could not be introduced in any of the patients, nor could the progression of the central nervous system (CNS) damage be stopped. The authors hope that the experiences they gathered will help to accelerate the diagnostic and therapeutic process in other patients with COVID-19-associated encephalopathy and result in introducing an effective treatment.
在感染新型冠状病毒2（SARS-CoV-2）的患者中，高达80%会出现神经系统表现。虽然其中大多数情况是良性的，但在某些患者中，病毒在中枢神经系统中的复制会导致认知功能以及基本生命功能严重受损。在这个病例系列中，作者详细描述了3例新型冠状病毒2感染病例，这些病例均并发了严重脑病。对每位患者连续的神经状态变化进行了描述，并给出了详细的影像学检查结果和临床后遗症。在讨论中，作者强调了所呈现病例在疾病过程中的相似之处以及检查结果的共同特征。在任何一位患者中都未能引入有效的病因治疗方法，也无法阻止中枢神经系统（CNS）损伤的进展。作者希望他们所积累的经验将有助于加快其他新型冠状病毒肺炎相关脑病患者的诊断和治疗进程，并促成有效的治疗方法问世。
