Ferrigno Bryan, Barba Romelia, Medina-Morales Esli, Trivedi Hirsh, Patwardhan Vilas, Bonder Alan
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
J Clin Med. 2022 Feb 18;11(4):1068. doi: 10.3390/jcm11041068.
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two types of chronic cholestatic liver disease (CCLD). Little is known regarding the relationship between these conditions and pregnancy. We performed a systematic review and meta-analysis regarding the maternal and fetal outcomes amongst patients with a known diagnosis of PBC and PSC undergoing pregnancy. Our analysis shows that patients with PBC and PSC who undergo pregnancy are at an increased risk of pre-term delivery, as well as the development of new or worsening pruritus during pregnancy. Additionally, patients with PBC are at higher risk of undergoing a biochemical disease flare during the postpartum period compared to during pregnancy. However, there were no documented cases of maternal mortality or development of decompensated cirrhosis during pregnancy or the postpartum period.
原发性胆汁性胆管炎（PBC）和原发性硬化性胆管炎（PSC）是两种慢性胆汁淤积性肝病（CCLD）。关于这些疾病与妊娠之间的关系，人们了解甚少。我们对已知诊断为PBC和PSC的患者在妊娠期间的母婴结局进行了系统评价和荟萃分析。我们的分析表明，患有PBC和PSC且怀孕的患者早产风险增加，以及在怀孕期间出现新的或加重的瘙痒。此外，与孕期相比，PBC患者在产后发生生化疾病发作的风险更高。然而，在孕期或产后没有记录到孕产妇死亡或失代偿期肝硬化发展的病例。
