Bonnet Camille, Masse Shirley, Benamar Hayat, Vilcu Ana-Maria, Swital Morgane, Hanslik Thomas, van der Werf Sylvie, Duval Xavier, Carrat Fabrice, Falchi Alessandra, Blanchon Thierry
Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), 75012 Paris, France.
UR7310 Bioscope, Université de Corse Pascal Paoli, 20250 Corte, France.
Life (Basel). 2022 Jan 21;12(2):163. doi: 10.3390/life12020163.
During the COVID-19 pandemic, several generic variants emerged, including the Alpha variant, with increased transmissibility compared to historical strains. We aimed to compare the evolution of the viral load between patients infected with the Alpha variant and those infected with the historical SARS-CoV-2 strains, while taking into account the time interval between the onset of symptoms and samples. We used data collected from patients with an acute respiratory infection (mild to moderate symptoms) and seen in consultation in primary care, included in a prospective longitudinal study, COVID-A. Patients performed four salivary samples during the follow-up. All patients who had at least one of the saliva samples test positive for SARS-CoV-2 were included in the analysis. Overall, 118 patients were included: 89 infected by the historical strain and 29 infected by the Alpha variant. Even though we tended to observe a higher viral load in the Alpha variant group, we found no significant difference in the evolution of the viral load in saliva samples between patients infected with the Alpha variant of the SARS-CoV-2 and those infected by historical strains when controlling for the time interval between the onset of symptoms and sampling.
在新冠疫情期间，出现了几种一般变体，包括阿尔法变体，与历史毒株相比，其传播性有所增加。我们旨在比较感染阿尔法变体的患者与感染历史新冠病毒毒株的患者之间病毒载量的演变情况，同时考虑症状出现与采样之间的时间间隔。我们使用了在前瞻性纵向研究COVID - A中收集的、在初级保健机构就诊的急性呼吸道感染（轻度至中度症状）患者的数据。患者在随访期间采集了四份唾液样本。所有至少有一份唾液样本检测出新冠病毒呈阳性的患者都纳入了分析。总体而言，共纳入了118名患者：89名感染历史毒株，29名感染阿尔法变体。尽管我们倾向于观察到阿尔法变体组的病毒载量更高，但在控制症状出现与采样之间的时间间隔后，我们发现感染新冠病毒阿尔法变体的患者与感染历史毒株的患者唾液样本中病毒载量的演变没有显著差异。
