National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, Pecs, Hungary.
Faculty of Sciences, Institute of Biology, University of Pécs, Pecs, Hungary.
Biol Futur. 2023 Jun;74(1-2):81-89. doi: 10.1007/s42977-023-00164-5. Epub 2023 May 18.
Genomic epidemiology is now a core component in investigating the spread of a disease during an outbreak and for future preparedness to tackle emerging zoonoses. During the last decades, several viral diseases arose and emphasized the importance of molecular epidemiology in tracking the dispersal route, supporting proper mitigation measures, and appropriate vaccine development. In this perspective article, we summarized what has been done so far in the genomic epidemiology field and what should be considered in the future. We traced back the methods and protocols employed over time for zoonotic disease response. Either to small outbreaks such as the severe acute respiratory syndrome (SARS) outbreak identified first in 2002 in Guangdong, China, or to a global pandemic like the one that we are experiencing now since 2019 when the severe acute respiratory syndrome 2 (SARS-CoV-2) virus emerged in Wuhan, China, following several pneumonia cases, and subsequently spread worldwide. We explored both the benefits and shortages encountered when relying on genomic epidemiology, and we clearly present the disadvantages of inequity in accessing these tools around the world, especially in countries with less developed economies. For effectively addressing future pandemics, it is crucial to work for better sequencing equity around the globe.
基因组流行病学现在是调查疾病暴发期间传播情况以及未来应对新发人畜共患病的核心组成部分。在过去几十年中,出现了几种病毒性疾病,强调了分子流行病学在追踪传播途径、支持适当的缓解措施和适当的疫苗开发方面的重要性。在本文中,我们总结了迄今为止在基因组流行病学领域所做的工作以及未来应考虑的事项。我们追溯了随着时间的推移用于应对人畜共患病的方法和协议。无论是像 2002 年在中国广东首次发现的严重急性呼吸系统综合症(SARS)这样的小暴发,还是像我们现在从 2019 年开始经历的那样的全球大流行,当时在中国武汉出现了严重急性呼吸系统综合症 2(SARS-CoV-2)病毒,随后在全球范围内传播。我们探讨了依赖基因组流行病学时遇到的好处和缺点,并且清楚地说明了在全球范围内获取这些工具方面存在的不平等的缺点,特别是在经济欠发达的国家。为了有效地应对未来的大流行,全球范围内必须努力实现更好的测序公平性。