Jin Young Ju, Kwon Mi Jung, Kim Ji Hee, Kim Joo-Hee, Choi Hyo Geun
Department of Otorhinolaryngology-Head & Neck Surgery, Wonkwang University Hospital, College of Medicine, Wonkwang University, Iksan 54538, Korea.
Department of Pathology, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
J Pers Med. 2022 Jan 20;12(2):133. doi: 10.3390/jpm12020133.
: The purpose of this study was to evaluate the association between thyroid cancer and breast cancer. : Data from the Korean National Health Insurance Service-Health Screening Cohort were collected from 2002 to 2013. In study I, 3949 thyroid cancer participants were 1:4 matched with 15,796 control I participants, and hazard ratios (HRs) with 95% confidence intervals (CIs) for breast cancer were evaluated using a stratified Cox proportional hazard model. In study II, 3308 breast cancer participants were 1:4 matched with 13,232 control II participants, and HRs with 95% CIs for thyroid cancer were assessed in the same way as in study I. In the subgroup analyses, associations were analyzed according to radioactive iodine (RAI) treatment and age (<60 years old and ≥60 years old). : The adjusted HR for breast cancer in the thyroid cancer group was 1.64 (95% CI = 1.13-2.39, = 0.010). The adjusted HR for thyroid cancer in the breast cancer group was 1.91 (95% CI = 1.47-2.49, < 0.001). In the subgroup analyses, the groups that were older and not treated with RAI treatment showed consistent results in study I, and the younger and older groups showed consistent results in study II. : Based on this cohort study, breast and thyroid cancer have a reciprocal positive association.
本研究的目的是评估甲状腺癌与乳腺癌之间的关联。收集了2002年至2013年韩国国民健康保险服务健康筛查队列的数据。在研究I中，3949名甲状腺癌参与者与15796名对照I参与者按1:4进行匹配，并使用分层Cox比例风险模型评估乳腺癌的风险比（HRs）及95%置信区间（CIs）。在研究II中，3308名乳腺癌参与者与13232名对照II参与者按1:4进行匹配，并以与研究I相同的方式评估甲状腺癌的HRs及95% CIs。在亚组分析中，根据放射性碘（RAI）治疗和年龄（<60岁和≥60岁）分析关联。甲状腺癌组中乳腺癌的校正HR为1.64（95% CI = 1.13 - 2.39，P = 0.010）。乳腺癌组中甲状腺癌的校正HR为1.91（95% CI = 1.47 - 2.49，P < 0.001）。在亚组分析中，年龄较大且未接受RAI治疗的组在研究I中显示出一致的结果，年龄较小和较大的组在研究II中显示出一致的结果。基于这项队列研究，乳腺癌和甲状腺癌存在相互正向关联。
