免疫调节剂的局部给药。
Local administration of immunomodulators.
作者信息
Pinsky C M
出版信息
Semin Oncol. 1986 Jun;13(2):141-3.
This summary of results with local BRM administration has been brief because the number of clinical situations in which this approach is applicable is quite limited. On the other hand, when applied in an appropriate patient population, clinical responses are frequent. In addition, detailed study of the effector cells and cytokines that appear in responding patients may yield information concerning the mechanism of action when BRM therapy is effective. Finally, comparison of the results from clinical trials with the results in experimental animals may help to further elucidate the mechanism by which BRMs exert antitumor effects.
局部给予生物反应调节剂（BRM）的结果总结较为简短，因为这种方法适用的临床情况数量相当有限。另一方面，当应用于合适的患者群体时，临床反应很常见。此外，对有反应患者体内出现的效应细胞和细胞因子进行详细研究，可能会得出BRM治疗有效时的作用机制相关信息。最后，将临床试验结果与实验动物的结果进行比较，可能有助于进一步阐明BRM发挥抗肿瘤作用的机制。
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