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花提取物通过调节肥大细胞对妊娠纹的缓解作用。

The Alleviating Effect of Flower Extract on Stretch Marks through Regulation of Mast Cells.

机构信息

Biospectrum, Life Science Institute, Yongin-si 16827, Korea.

出版信息

Molecules. 2022 Feb 14;27(4):1274. doi: 10.3390/molecules27041274.

DOI:10.3390/molecules27041274
PMID:35209065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8877584/
Abstract

Striae distensae (SD) or stretch marks are common linear scars of atrophic skin with disintegrating extracellular matrix (ECM) structures. Although fibroblasts contribute to the construction of ECM structure in SD, some studies have reported that mast cell degranulation causes the disruption of ECM in early SD lesions. flower (LIF) has traditionally been used in India as a diuretic. However, little is known about the effect and molecular action of flower extract (LIFE) on alleviating SD. This study evaluated the effects of LIFE on mast cell degranulation and the synthesis of ECM components in fibroblasts. LIFE inhibits the adhesion of rat basophilic leukemia (RBL) cells, RBL-2H3 on fibronectin (FN) and the expression of integrin, a receptor for FN, thereby reducing focal adhesion kinase (FAK) phosphorylation. In addition, LIFE attenuated the allergen-induced granules and cytokine interleukin 3 (IL-3) through the adhesion with FN. Moreover, the conditioned medium (CM) of activated mast cells decreases the synthesis of ECM components, and LIFE restores the abnormal expressions induced by activated mast cells. These results demonstrate that LIFE suppresses FN-induced mast cell activation and promotes the synthesis of ECM components in fibroblast, which indicates that LIFE may be a useful cosmetic agent for SD treatment.

摘要

妊娠纹（SD）或伸展纹是常见的萎缩性皮肤线性瘢痕，其细胞外基质（ECM）结构崩解。尽管成纤维细胞有助于 SD 中 ECM 结构的构建，但一些研究报道肥大细胞脱颗粒导致早期 SD 病变中 ECM 的破坏。番红花（LIF）在印度传统上被用作利尿剂。然而，关于番红花提取物（LIFE）对缓解 SD 的作用及其分子作用知之甚少。本研究评估了 LIFE 对肥大细胞脱颗粒和成纤维细胞 ECM 成分合成的影响。LIFE 抑制大鼠嗜碱性白血病（RBL）细胞、RBL-2H3 在纤维连接蛋白（FN）上的黏附以及 FN 受体整联蛋白的表达，从而减少粘着斑激酶（FAK）磷酸化。此外，LIFE 通过与 FN 黏附来减弱过敏原诱导的颗粒和细胞因子白细胞介素 3（IL-3）。此外，活化的肥大细胞的条件培养基（CM）降低 ECM 成分的合成，而 LIFE 恢复由活化的肥大细胞诱导的异常表达。这些结果表明，LIFE 抑制 FN 诱导的肥大细胞激活并促进成纤维细胞中 ECM 成分的合成，这表明 LIFE 可能是治疗 SD 的有用化妆品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/038690148ff4/molecules-27-01274-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/8d13609d007f/molecules-27-01274-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/c592f16a4912/molecules-27-01274-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/8516d47c91c7/molecules-27-01274-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/dd59a9fa8132/molecules-27-01274-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/038690148ff4/molecules-27-01274-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/8d13609d007f/molecules-27-01274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/89b24971bacc/molecules-27-01274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/d8450572246a/molecules-27-01274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/654735aa5ad4/molecules-27-01274-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/c592f16a4912/molecules-27-01274-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/8516d47c91c7/molecules-27-01274-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/dd59a9fa8132/molecules-27-01274-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b08/8877584/038690148ff4/molecules-27-01274-g008.jpg

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