College of Nursing, Mo-Im Kim Nursing Research Institute, Yonsei University, Seoul, Korea.
Department of Information & Statistics, Chungbuk National University, Cheongju, Korea.
Epidemiol Health. 2022;44:e2022029. doi: 10.4178/epih.e2022029. Epub 2022 Feb 21.
Opioids are prescribed to treat moderate to severe pain. We investigated recent trends in opioid (morphine, oxycodone, fentanyl, and hydromorphone) prescriptions using data from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015.
The morphine milligram equivalent (MME) was calculated to standardize the relative potency of opioids. The number (cases) or amount (MME) of annual opioid prescriptions per 10,000 registrants was computed to analyze trends in opioid prescriptions after age standardization. Joinpoint regression analysis was conducted to calculate the annual percentage change and average annual percentage change (AAPC).
The number (cases) of prescriptions per 10,000 registrants increased from 0.07 in 2002 to 41.23 in 2015 (AAPC, 76.0%; 95% confidence interval [CI], 61.6 to 91.7). The MME per 10,000 registrants increased from 15.06 in 2002 to 40,727.80 in 2015 (AAPC, 103.0%; 95% CI, 78.2 to 131.3). The highest AAPC of prescriptions and MME per 10,000 registrants were observed in the elderly (60-69 years) and in patients treated at general hospitals. Fentanyl prescriptions increased most rapidly among the 4 opioids.
Consumption of opioids greatly increased in Korea over the 14-year study period.
阿片类药物用于治疗中重度疼痛。我们利用韩国健康保险服务-国家样本队列 2002 至 2015 年的数据，调查了阿片类药物（吗啡、羟考酮、芬太尼和氢吗啡酮）处方的近期趋势。
计算吗啡毫克当量（MME）以标准化阿片类药物的相对效力。每年每 10000 名登记患者的阿片类药物处方数量（例数）或剂量（MME）标准化后进行分析。采用 Joinpoint 回归分析计算年度百分比变化和平均年百分比变化（AAPC）。
每年每 10000 名登记患者的处方数量从 2002 年的 0.07 例增加到 2015 年的 41.23 例（AAPC，76.0%；95%置信区间[CI]，61.6 至 91.7）。每年每 10000 名登记患者的 MME 从 2002 年的 15.06 例增加到 2015 年的 40727.80 例（AAPC，103.0%；95%CI，78.2 至 131.3）。处方和 MME 每 10000 名登记患者的最高 AAPC 见于老年人（60-69 岁）和在综合医院接受治疗的患者。4 种阿片类药物中，芬太尼的处方增加最快。
在 14 年的研究期间，韩国阿片类药物的使用大大增加。
