Perri-Plandé Joelle, Miremont-Salamé Ghada, Micallef Joëlle, Herman Cameron, Baumevieille Marie, Abriat Frédéric, Lapeyre-Mestre Maryse, Haramburu Françoise, Daveluy Amélie
Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, Bordeaux, France.
Drug Saf. 2022 Jan;45(1):37-44. doi: 10.1007/s40264-021-01124-5. Epub 2021 Oct 29.
Analgesics are among the most widely used drugs worldwide. This study describes the population treated with narcotic analgesics, their therapeutic indications and how the data have evolved over a decade.
A cross-sectional, national, multicentre survey study was conducted that included surveys taken every year from 2007 to 2019 in a national sample of 1500 randomly selected dispensing pharmacies.
The mean age of patients, mostly women (around 60%), remained stable over the study period (63.2 ± 17.1 years in 2007, 68.2 ± 17.2 years in 2019). The proportion of patients treated for more than 3 months increased from 2007 to 2019. Most prescriptions involved morphine, oxycodone and fentanyl (98.5% of all prescriptions in 2019). Morphine prescriptions dropped dramatically from 49.6% (2007) to 32.3% (2019) of the total narcotic analgesics. Fentanyl prescriptions varied from 40.1% in 2007 to 32.2% in 2019. Prescriptions of oxycodone, regardless of the indication, increased steadily from 2007, from 8.3 to 34% in 2019, becoming the most prescribed narcotic analgesic for the first time since the beginning of the survey.
This study demonstrates how narcotic opioids are prescribed, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone.
镇痛药是全球使用最广泛的药物之一。本研究描述了接受麻醉性镇痛药治疗的人群、他们的治疗适应症以及这些数据在十年间的变化情况。
开展了一项全国性、多中心的横断面调查研究，其中包括2007年至2019年每年对1500家随机选取的全国性配药药房样本进行的调查。
在研究期间，患者的平均年龄保持稳定，大多数为女性（约60%）（2007年为63.2±17.1岁，2019年为68.2±17.2岁）。接受治疗超过3个月的患者比例从2007年到2019年有所增加。大多数处方涉及吗啡、羟考酮和芬太尼（2019年占所有处方的98.5%）。吗啡处方在麻醉性镇痛药总数中的占比从2007年的49.6%急剧降至2019年的32.3%。芬太尼处方从2007年的40.1%变化至2019年的32.2%。无论适应症如何，羟考酮的处方量自2007年起稳步增加，从8.3%增至2019年的34%，自调查开始以来首次成为处方量最多的麻醉性镇痛药。
这项研究展示了在卫生专业人员的积极参与下麻醉性阿片类药物的处方情况，并证实了羟考酮处方量的显著增加。
