Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
North Colombo Teaching Hospital, Ragama, Sri Lanka.
J Med Case Rep. 2022 Feb 25;16(1):82. doi: 10.1186/s13256-022-03282-1.
Sweet syndrome is a rare cause of acute fever and painful erythematous skin plaques. Erythema nodosum is acute or chronic tender erythematous skin nodules of bilateral shins. The concurrent presence of both dermatoses is rare but reported in the literature. There are no reported cases of recurrent and sequential Sweet syndrome and erythema nodosum without an underlying secondary cause.
We report the case of a 64-year-old Asian woman, who had possible Sweet syndrome 12 years ago and biopsy-proven erythema nodosum 5 years ago, presenting with an acute episode of Sweet syndrome. Extensive investigations did not reveal any underlying secondary cause.
Recurrent Sweet syndrome and sequential presence with erythema nodosum raises suspicion if Sweet syndrome and erythema nodosum are different presentations of one disease, which warrants further study. This case proves that recurrent Sweet syndrome and erythema nodosum can occur in healthy individuals without an underlying malignancy or secondary cause.
Sweet 综合征是一种罕见的急性发热伴疼痛性红斑斑块的病因。结节性红斑是双侧小腿急性或慢性触痛性红斑结节性皮肤病。同时存在这两种皮肤病的情况很少见，但有文献报道。目前尚无报告称在无潜在继发原因的情况下，Sweet 综合征和结节性红斑反复发作和相继出现。
我们报告了一例 64 岁的亚裔女性，她 12 年前可能患有 Sweet 综合征，5 年前经活检证实患有结节性红斑，现出现急性 Sweet 综合征发作。广泛的检查并未发现任何潜在的继发原因。
如果 Sweet 综合征和结节性红斑是同一种疾病的不同表现，那么反复出现 Sweet 综合征和先后出现结节性红斑会引起怀疑，这需要进一步研究。本病例证明，在没有潜在恶性肿瘤或继发原因的情况下，反复发生的 Sweet 综合征和结节性红斑也可能发生在健康个体中。
