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纤维肌痛患者中甲状腺激素过度使用的情况:初级保健中的横断面研究。

Excess use of thyroid hormone treatment among patients with fibromyalgia: a cross-sectional study in primary health care.

机构信息

Department of General Practice, Faculty of Medicine and Health Technology, Tampere University, Arvo-Building B222, PL100, 33014, Tampere, Finland.

Centre for General Practice, Tampere University Hospital, Tampere, Finland.

出版信息

BMC Res Notes. 2022 Feb 24;15(1):83. doi: 10.1186/s13104-022-05971-y.

Abstract

OBJECTIVE

From previous studies, it is known that the association between fibromyalgia and thyroid autoimmunity diseases exists. On the other hand, it was recently suggested that in many cases thyroid hormone treatment might be unnecessary. The aim of our study is to explore the thyroid hormone treatment among primary health care fibromyalgia patients. Our study is cross-sectional and based on fibromyalgia study from the city of Nokia Health Center. Clinical examination was performed to participants, patients filled five questionnaires and information from electronic patient records was gathered. In addition to other parameters, we studied patient's thyroid function levels at the beginning of thyroid hormone treatment.

RESULTS

From those patients participating in the study (n = 103), 34% (n = 33) had thyroid hormone treatment. From those taking thyroid hormone treatment, 48% (n = 16) had information regarding the initial TSH and T4-V levels at the beginning of the treatment. 37% (n = 6) of them had normal thyroid function. Small sample size and data gathered from single health center effects on the generalizability of our findings. However, we suggest further studies to confirm the potential association between fibromyalgia and inappropriate thyroid hormone treatment.

摘要

目的

从以往的研究中可知,纤维肌痛与甲状腺自身免疫性疾病之间存在关联。另一方面,最近有人提出,在许多情况下,甲状腺激素治疗可能是不必要的。我们的研究旨在探讨初级保健纤维肌痛患者中的甲状腺激素治疗。我们的研究是横断面的,基于诺基亚健康中心的纤维肌痛研究。对参与者进行了临床检查,患者填写了五份问卷,并收集了电子患者记录中的信息。除了其他参数外,我们还研究了患者在开始甲状腺激素治疗时的甲状腺功能水平。

结果

在参加研究的患者中(n=103),有 34%(n=33)接受了甲状腺激素治疗。在接受甲状腺激素治疗的患者中,有 48%(n=16)有治疗开始时 TSH 和 T4-V 水平的初始信息。其中 37%(n=6)的患者甲状腺功能正常。样本量小以及从单个健康中心收集的数据影响了我们研究结果的普遍性。然而,我们建议进行进一步的研究,以确认纤维肌痛与不适当的甲状腺激素治疗之间的潜在关联。

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本文引用的文献

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Levothyroxine overuse: time for an about face?左甲状腺素的过度使用:是时候转变态度了吗?
Lancet Diabetes Endocrinol. 2017 Apr;5(4):246-248. doi: 10.1016/S2213-8587(16)30276-5. Epub 2016 Oct 28.
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Fibromyalgia: A Critical and Comprehensive Review.纤维肌痛:一项批判性与综合性综述。
Clin Rev Allergy Immunol. 2015 Oct;49(2):100-51. doi: 10.1007/s12016-015-8509-4.
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Psychiatric and cognitive manifestations of hypothyroidism.甲状腺功能减退的精神和认知表现。
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):377-83. doi: 10.1097/MED.0000000000000089.
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Fibromyalgia: a clinical review.纤维肌痛症:临床综述。
JAMA. 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266.
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Association between thyroid autoimmunity and fibromyalgia.甲状腺自身免疫与纤维肌痛之间的关联。
Exp Clin Endocrinol Diabetes. 2012 Jul;120(7):401-4. doi: 10.1055/s-0032-1309008. Epub 2012 Apr 27.

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