分支杆菌副结核亚种和髓鞘碱性蛋白特异性表位被视神经脊髓炎谱系障碍患者的血清高度识别。
Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder.
机构信息
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
Department of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
出版信息
J Neuroimmunol. 2018 May 15;318:97-102. doi: 10.1016/j.jneuroim.2018.02.013. Epub 2018 Feb 28.
Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP, IRF5) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs. 5%, p < 0.0002 and 50% vs. 2%, p < 0.0001, respectively), while, unlike in MS, responsiveness to EBV was similar.
EB 病毒（EBV）是与视神经脊髓炎谱系疾病（NMOSD）相关的主要环境因素。继报道抗分枝杆菌副结核亚种（MAP）衍生的肽的抗体在多发性硬化症（MS）中流行率增加的研究之后，这些肽与 EBV 和人类表位（MBP、IRF5）具有同源性，我们研究了这些抗原的血清反应是否显示出 NMOSD 的特异性模式。与健康对照组相比，34 名 NMOSD 患者的血清中针对 MAP 和 MBP 的抗体水平升高（分别为 44%比 5%，p<0.0002 和 50%比 2%，p<0.0001），而与 MS 不同，对 EBV 的反应性相似。
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