水解蛋白配方预防早产儿胃肠道疾病和体格生长的效果：Meta 分析。
Effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants: a Meta analysis.
机构信息
Department of Neonatology, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Feb 15;24(2):169-175. doi: 10.7499/j.issn.1008-8830.2109124.
OBJECTIVES
To systematically evaluate the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical development in preterm infants.
METHODS
A computerized search was performed in the databases including China National Knowledge Infrastructure, Wanfang Data, Weipu, PubMed, Embase, and the Cochrane Library to identify randomized controlled trials of the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants. RevMan 5.3 software was used to perform a Meta analysis for the included studies.
RESULTS
A total of 7 randomized controlled studies were included. The results of Meta analysis showed that compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula could reduce the risk of neonatal necrotizing enterocolitis (=0.40, =0.04) and feeding intolerance (=0.40, =0.005), and had no significant effect on the growth of weight, length and head circumference (>0.05).
CONCLUSIONS
Compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula in preterm infants may reduce the occurrence of necrotizing enterocolitis and feeding intolerance, and can meet the nutrient requirement of physical development. However, the evidence is limited, and the results of this study cannot support the routine prophylactic use of hydrolyzed protein formula in preterm infants.
目的
系统评价水解蛋白配方预防应用对早产儿胃肠道疾病和体格发育的影响。
方法
计算机检索中国知网、万方数据、维普、PubMed、Embase、Cochrane 图书馆，收集预防应用水解蛋白配方对早产儿胃肠道疾病和体格生长影响的随机对照试验，采用 RevMan 5.3 软件进行 Meta 分析。
结果
共纳入 7 项随机对照试验。Meta 分析结果显示，与普通配方奶粉相比，水解蛋白配方预防应用可降低新生儿坏死性小肠结肠炎的发病风险[比值比（OR）=0.40，=0.04]和喂养不耐受的发生风险[OR=0.40，=0.005]，但对体重、身长及头围的增长无明显影响（均>0.05）。
结论
与普通配方奶粉相比，水解蛋白配方预防应用于早产儿可能降低坏死性小肠结肠炎和喂养不耐受的发生风险，能够满足体格发育的营养需求。但受纳入研究数量和质量的限制，本研究结果尚不能支持早产儿常规预防应用水解蛋白配方。
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