From the Department of Radiology (M.S.R., L.K., A.N.O., O.K.), Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
The Sackler Faculty of Medicine (M.S.R., L.K., A.N.O., O.K.), Tel Aviv University, Tel Aviv, Israel.
AJNR Am J Neuroradiol. 2022 Mar;43(3):480-485. doi: 10.3174/ajnr.A7437. Epub 2022 Feb 24.
The fornix-fimbria complex is mainly involved in emotions and memory. In brain MR imaging studies of young children, we have occasionally noted DWI hyperintensity in this region. The significance of this finding remains unclear. This study evaluated the DWI signal in the fornix-fimbria complex of children 0-2 years of age, including the frequency of signal hyperintensity and clinical context.
Brain MR imaging of 714 children 0-2 years of age (mean, 11 months), performed between September 2018 and May 2021, was reviewed and evaluated for DWI signal changes in the fornix-fimbria. All children with available MR imaging studies including DWI were included. Children with poor image quality, poor visualization of the fornix-fimbria region, and missing medical data were excluded. Additional imaging findings were also evaluated. Demographic data were retrieved from the medical files. We compared the ADC values of the fimbria and fornix between children with and without signal changes. The unpaired 2-tailed Student test and χ test were used for statistical analysis.
DWI signal hyperintensity of the Fornix-fimbria complex was noted in 53 (7.4%) children (mean age, 10 months). Their mean ADC values were significantly lower than those of the children with normal DWI findings (< .05). About half of the children had otherwise normal MR imaging findings. When detected, the most common abnormality was parenchymal volume loss (15%). The most common indication for imaging was seizures (26.5%).
DWI hyperintensity in the fornix-fimbria complex was detected in 7.4% of children 0-2 years of age. The etiology is not entirely clear, possibly reflecting a transient phenomenon.
穹窿-伞部复合体主要与情绪和记忆有关。在对儿童的脑部磁共振成像研究中，我们偶尔会注意到该区域的弥散加权成像（DWI）信号高。其意义尚不清楚。本研究评估了 0-2 岁儿童穹窿-伞部复合体的 DWI 信号，包括信号高的频率和临床背景。
回顾性分析了 2018 年 9 月至 2021 年 5 月期间进行的 714 名 0-2 岁（平均 11 个月）儿童的脑部磁共振成像资料，评估了穹窿-伞部 DWI 信号改变。所有有 DWI 磁共振成像研究的儿童均纳入本研究。排除图像质量差、穹窿-伞部区域显示不佳和缺少医学资料的儿童。还评估了其他影像学发现。从病历中检索了人口统计学资料。我们比较了有和无信号改变的儿童的伞部和穹窿的 ADC 值。使用配对和非配对 2 尾 Student 检验和 χ 检验进行统计学分析。
53 名（7.4%）儿童的穹窿-伞部复合体 DWI 信号高（平均年龄 10 个月）。他们的平均 ADC 值明显低于 DWI 正常发现的儿童（<0.05）。大约一半的儿童有其他正常的磁共振成像结果。当发现异常时，最常见的异常是实质体积损失（15%）。最常见的成像指征是癫痫发作（26.5%）。
0-2 岁儿童的穹窿-伞部复合体 DWI 信号高发生率为 7.4%。病因尚不完全清楚，可能反映了一种短暂的现象。
