Frantz E G, Henry G W, Lucas C L, Keagy B A, Lores M E, Criado E, Ferreiro J I, Wilcox B R
Ultrasound Med Biol. 1986 May;12(5):379-85. doi: 10.1016/0301-5629(86)90195-x.
Pulmonary artery blood flow velocity was measured in 15 dogs by a recently developed direct intraluminal pulsed Doppler technique. Changes in velocity characteristics under conditions of experimentally induced hypoxic pulmonary hypertension were observed. Experimental conditions (fractional inspired oxygen concentration = 0.10) produced significant increases in mean pulmonary artery pressure and pulmonary vascular resistance. Overall and maximal negative velocity increased with pulmonary hypertension. Negative velocity occurred predominantly in the posterior half of the pulmonary artery during both control and experimental conditions. With pulmonary hypertension, diastolic negative velocity increased only in the posterior half of the pulmonary artery and systolic negative velocity decreased only in the anterior half. More basic knowledge of pulmonary artery blood flow characteristics may facilitate an informed approach to noninvasive detection of pulmonary hypertension. Direct measurements by this recently developed intraluminal technique will be useful in studying various conditions with altered pulmonary blood flow.
采用最近开发的直接腔内脉冲多普勒技术，对15只犬的肺动脉血流速度进行了测量。观察了实验性诱导的低氧性肺动脉高压条件下速度特征的变化。实验条件（吸入氧分数 = 0.10）使平均肺动脉压和肺血管阻力显著增加。随着肺动脉高压的出现，总体和最大负向速度增加。在对照和实验条件下，负向速度主要出现在肺动脉后半段。随着肺动脉高压的发展，舒张期负向速度仅在肺动脉后半段增加，而收缩期负向速度仅在前半段降低。对肺动脉血流特征有更多的基础知识，可能有助于采用明智的方法对肺动脉高压进行无创检测。通过这种最近开发的腔内技术进行直接测量，将有助于研究各种肺血流改变的情况。
