Cowles J W, Spitalnik S L, Blumberg N
Vox Sang. 1986;50(3):164-8. doi: 10.1111/j.1423-0410.1986.tb04871.x.
Utilizing a kinetic enzyme-linked antiglobulin binding assay, eight examples of anti-Lea were detected in individuals whose Lewis phenotype is Le(a-b+). These antibodies were not detectable by routine hemagglutination techniques, but were indistinguishable from anti-Lea made by Le(a-b-) individuals in terms of their immunologic fine specificity. However, unlike most anti-Lea antibodies from Le(a-b-) individuals, none of the anti-Lea antibodies had an IgG component. Anti-Lea antibodies in Le(a-b+) individuals may represent immune responses on the continuum between autoimmunity and alloimmunity.
利用一种动力学酶联抗球蛋白结合试验，在Lewis血型表型为Le(a-b+)的个体中检测到8例抗-Lea抗体。这些抗体用常规血凝技术无法检测到，但就其免疫精细特异性而言，与Le(a-b-)个体产生的抗-Lea抗体并无区别。然而，与大多数来自Le(a-b-)个体的抗-Lea抗体不同，这些抗-Lea抗体均无IgG成分。Le(a-b+)个体中的抗-Lea抗体可能代表自身免疫和同种免疫连续体上的免疫反应。
