Spitalnik S, Cowles J, Cox M T, Blumberg N
Vox Sang. 1985;48(4):235-8. doi: 10.1111/j.1423-0410.1985.tb00177.x.
Lewis blood group antibodies rarely, if ever, cause hemolytic disease of the newborn. This observation has been attributed to the absence both of Lewis antigens on fetal cells and of maternal IgG Lewis antibody. In the present study, sera from 13 mother-infant pairs were tested for the presence of anti-Lewis (a) by hemagglutination and by a sensitive and specific kinetic enzyme-linked immunosorbent assay. By routine hemagglutination methods, anti-Lea was present in all maternal samples but absent in all cord samples. By kinetic enzyme-linked immunosorbent assay, IgG anti-Lea was present in 13 of 13 maternal samples and in 12 of 13 cord samples. These results indicate that IgG anti-Lea antibodies are common and do cross the placenta. This suggests that they do not cause hemolytic disease of the newborn because of the low levels of Lewis antigens on fetal red cells.
Lewis血型抗体极少（即便有也极为罕见）引起新生儿溶血病。这一现象被归因于胎儿细胞上缺乏Lewis抗原以及母体IgG Lewis抗体的缺乏。在本研究中，通过血凝试验以及一种灵敏且特异的动力学酶联免疫吸附测定法，对13对母婴的血清进行了抗Lewis（a）检测。采用常规血凝方法，所有母体样本中均存在抗-Lea，而所有脐带血样本中均未检测到。通过动力学酶联免疫吸附测定法，13份母体样本中的13份以及13份脐带血样本中的12份检测到IgG抗-Lea。这些结果表明，IgG抗-Lea抗体很常见且确实会穿过胎盘。这表明它们不会引起新生儿溶血病，因为胎儿红细胞上的Lewis抗原水平较低。
