Burekovic Azra, Haskovic Edhem, Ceric Faruk, Halilovic Dzenana
Clinical Center University of Sarajevo.
Faculty of Medicine, University of Sarajevo.
Mater Sociomed. 2021 Dec;33(4):240-243. doi: 10.5455/msm.2021.33.240-243.
Hyperglycemia, polyuria, and glycosuria are all risk factors for the frequency of urinary tract infections in patients with diabetes.
The aim of this study is to establish correlation between inflammatory and biochemical parameters in patients with diabetes and urinary tract infection.
Total number 116 patients were monitored, at the ages between 18-95 years, with diabetes and urinary tract infection, of which 59.49% women and 40.51% men. Patients were with a duration of diabetes from 0 to over 20 years, with an average fasting glycemia of 9.54 mmol/l, and postprandial glycemia 13.94 mmol/l, HbA1C 9.92%, which have been poorly regulated in the last 3-4 months. Inflammatory parameters SE, CRP, leukocytes were correlated with inflammatory parameters of urine sediment and positive urine cultures.
Average values of urea, creatinine, and proteinuria were positively correlated with the duration of diabetes. Escherichia coli, Enterococcus feecalis, and Candida albicans were the most common pathogens isolated in urine culture, 51 patients had reinfection once, 39 patients had two reinfections, and 26 patients had three reinfections during the 6-month follow-up.
Duration of diabetes, long-term poor glycoregulation lead to microangiopathic changes in the kidneys in the form of diabetic nephropathy with retention of nitrogenous substances of urea, creatinine with proteinuria, and acute hyperglycemia, polyuria and glycosuria, further leading to frequent urinary tract infections.
高血糖、多尿和糖尿都是糖尿病患者发生尿路感染的危险因素。
本研究旨在建立糖尿病合并尿路感染患者炎症和生化参数之间的相关性。
共监测了116例年龄在18 - 95岁之间的糖尿病合并尿路感染患者，其中女性占59.49%，男性占40.51%。患者糖尿病病程从0年至20年以上，平均空腹血糖为9.54 mmol/l，餐后血糖为13.94 mmol/l，糖化血红蛋白为9.92%，在过去3 - 4个月血糖控制不佳。将炎症参数SE、CRP、白细胞与尿沉渣炎症参数及尿培养阳性结果进行相关性分析。
尿素、肌酐和蛋白尿的平均值与糖尿病病程呈正相关。大肠埃希菌、粪肠球菌和白色念珠菌是尿培养中最常见的分离病原体，在6个月的随访期间，51例患者发生过1次再感染，39例患者发生过2次再感染，26例患者发生过3次再感染。
糖尿病病程、长期血糖控制不佳会导致肾脏微血管病变，表现为糖尿病肾病，伴有尿素、肌酐等含氮物质潴留及蛋白尿，以及急性高血糖、多尿和糖尿，进而导致频繁发生尿路感染。
