Li Huixia, Zhang Liying, Tian Hong, Zhang Song, Zhang Xueyan, Zhang Han, Chen Yujing, Qi Wenping, Wu Xiaoying, Jiang Hongmei, Yang Hailong, Yang Yajun, Liu Lei, Zhang Guisen
Department of Retina, Inner Mongolia Chaoju Eye Hospital, Hohhot, China.
Department of Cataract, Ulanqab Chaoju Eye Hospital, Ulanqab, China.
Front Pharmacol. 2022 Feb 8;13:808440. doi: 10.3389/fphar.2022.808440. eCollection 2022.
The purpose of the study is to evaluate the effects of 0.01% atropine eye drops on accommodative system parameters among teenagers with low myopia. Ninety-five myopic teenagers [39 boys (8.69 ± 2.473) and 56 girls (8.54 ± 2.054) aged 5-17 years] with no history of eye disease were enrolled. Biometric and accommodative system parameters were evaluated before and at 1 week, 1 month, 3 months, and 6 months of 0.01% atropine eye drop instillation. Participants without accommodative demand at 6 months demonstrated insignificant changes after the atropine instillation (all > 0.05). Nevertheless, there were significant differences in accommodative sensitivity, accommodative amplitude, accommodative responsiveness, and negative relative accommodation (NRA) at 3 months compared with baseline after atropine instillation (all < 0.05). Except spherical equivalent refraction, cornea thickness, intraocular pressure, and axial length were stable after the 0.01% atropine instillation (all > 0.05). Morphologically, current measurements suggested that 0.01% atropine had favorable reduction of accommodation for childhood low myopia over a half-year period.
本研究的目的是评估0.01%阿托品滴眼液对低度近视青少年调节系统参数的影响。招募了95名无眼部疾病史的近视青少年[39名男孩（8.69±2.473）和56名女孩（8.54±2.054），年龄在5至17岁之间]。在滴入0.01%阿托品滴眼液之前以及滴入后1周、1个月、3个月和6个月时，对生物测量和调节系统参数进行评估。在6个月时无调节需求的参与者在滴入阿托品后显示出不显著的变化（均>0.05）。然而，与滴入阿托品后的基线相比，在3个月时调节灵敏度、调节幅度、调节反应性和负相对调节（NRA）存在显著差异（均<0.05）。除等效球镜度、角膜厚度、眼压和眼轴长度在滴入0.01%阿托品后保持稳定（均>0.05）。在形态学上，目前的测量表明，0.01%阿托品在半年时间内对儿童低度近视的调节有良好的降低作用。
