Mitsukawa Tadahiro, Suzuki Yumi, Momota Yosuke, Suzuki Shun, Yamada Masakazu
Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
J Clin Med. 2021 Sep 25;10(19):4384. doi: 10.3390/jcm10194384.
In this paper, we assessed the short-term effects of 0.01% atropine eye drops on anterior segment parameters by performing ocular biometry using a swept-source anterior segment optical coherence tomography system (AS-OCT). We recruited 17 healthy volunteers (10 men and 7 women aged 24-35 years) with no history of eye disease. Participants without accommodative demand demonstrated significant mydriasis 1 h after the atropine instillation (4.58 ± 0.77 to 5.41 ± 0.83 mm). Pupil diameters with a 5 diopter (D) accommodative stimulus at 1 h (4.70 ± 1.13 mm) and 24 h (4.05 ± 1.06 mm) after atropine instillation were significantly larger than those at baseline (3.71 ± 0.84 mm). Barring pupil diameter, no other biometric parameters significantly changed at any point in time after atropine instillation without accommodative demand. However, with an accommodative stimulus, anterior chamber depth (ACD) at 1 h and posterior curvature of the lens at 1 and 24 h were both significantly larger than those before atropine instillation. Using AS-OCT, we detected a slight decrease in the accommodation response of ocular biometric components evoked by 0.01% atropine instillation. Morphologically, our measurements suggested a change in the ACD and horizontal radius of the lens' posterior surface curvatures due to the subtle reduction of accommodation.
在本文中，我们使用扫频源眼前节光学相干断层扫描系统（AS-OCT）进行眼生物测量，评估了0.01%阿托品滴眼液对眼前节参数的短期影响。我们招募了17名无眼部疾病史的健康志愿者（10名男性和7名女性，年龄在24 - 35岁之间）。无调节需求的参与者在滴入阿托品1小时后出现显著散瞳（从4.58±0.77毫米至5.41±0.83毫米）。滴入阿托品后1小时（4.70±1.13毫米）和24小时（4.05±1.06毫米）时，5屈光度（D）调节刺激下的瞳孔直径显著大于基线时（3.71±0.84毫米）。除瞳孔直径外，在无调节需求的情况下，滴入阿托品后的任何时间点，其他生物测量参数均无显著变化。然而，在有调节刺激时，1小时时的前房深度（ACD）以及1小时和24小时时晶状体的后曲率均显著大于滴入阿托品前。通过AS-OCT，我们检测到滴入0.01%阿托品后眼生物测量成分的调节反应略有下降。从形态学上看，我们的测量结果表明，由于调节的细微减少，ACD和晶状体后表面曲率的水平半径发生了变化。
