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TMDCT 汤通过调节 Treg/Th17 平衡对嗜酸性粒细胞性哮喘的抗炎及抗哮喘作用

Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/Th17 Balance.

作者信息

Zhou Yumei, Zhao Haihong, Wang Tieshan, Zhao Xiaoshan, Wang Ji, Wang Qi

机构信息

National Institute of TCM Constitution and Preventive Medicine, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

出版信息

Front Pharmacol. 2022 Feb 8;13:819728. doi: 10.3389/fphar.2022.819728. eCollection 2022.

DOI:10.3389/fphar.2022.819728
PMID:35211018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8861319/
Abstract

Tuo-Min-Ding-Chuan decoction (TMDCT) is a Traditional Chinese Medicine (TCM) formula consisting of twelve herbs that can relieve the symptoms and treat allergic asthma. Yet, the underlying mechanism of action is still unclear. In this study, we investigated the effect of TMDCT in regulating Treg/Th17 cells immune balance and explored potential metabolic and gut biomarkers associated with Treg and Th17 cells in eosinophilic asthma mice treated by TMDCT. We found that TMDCT increases Treg cells percentage and decreases Th17 cells percentage in the ovalbumin (OVA) -induced eosinophilic asthma mice model. Furthermore, Imidazoleacetic acid, dL-glutamine, L-pyroglutamic acid, 2-deoxy-d-glucose were preliminary identified as biomarkers in plasma metabolites treated by TMDCT, meanwhile genus , genus and genus were preliminary identified as gut microbiota biomarkers after TMDCT treatment. These results provide an experimental foundation for the treatment of allergic asthma with Chinese herbal compounds.

摘要

脱敏定喘汤（TMDCT）是一种由十二味中药组成的中药方剂，可缓解症状并治疗过敏性哮喘。然而，其潜在的作用机制仍不清楚。在本研究中，我们研究了TMDCT在调节Treg/Th17细胞免疫平衡方面的作用，并探索了在TMDCT治疗的嗜酸性粒细胞性哮喘小鼠中与Treg和Th17细胞相关的潜在代谢和肠道生物标志物。我们发现，在卵清蛋白（OVA）诱导的嗜酸性粒细胞性哮喘小鼠模型中，TMDCT可增加Treg细胞百分比并降低Th17细胞百分比。此外，咪唑乙酸､DL-谷氨酰胺､L-焦谷氨酸､2-脱氧-D-葡萄糖被初步鉴定为TMDCT处理的血浆代谢物中的生物标志物，同时，属､属和属被初步鉴定为TMDCT处理后的肠道微生物群生物标志物。这些结果为用中药复方治疗过敏性哮喘提供了实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/054c641d8459/fphar-13-819728-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/6d67ab342fe0/fphar-13-819728-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/847ec8480a09/fphar-13-819728-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/f5398c06dc74/fphar-13-819728-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/6375583fff56/fphar-13-819728-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/37075a3d31cf/fphar-13-819728-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/054c641d8459/fphar-13-819728-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/6d67ab342fe0/fphar-13-819728-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/847ec8480a09/fphar-13-819728-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/f5398c06dc74/fphar-13-819728-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/6375583fff56/fphar-13-819728-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/37075a3d31cf/fphar-13-819728-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abdb/8861319/054c641d8459/fphar-13-819728-g006.jpg

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