Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai, China.
Department of Nephropathy, The Third Affiliated Hospital of Shenzhen University, Luohu Hospital Group, Shenzhen, China.
Neural Plast. 2022 Feb 15;2022:4217593. doi: 10.1155/2022/4217593. eCollection 2022.
Chronic pain patients often develop mental disorders, and anxiety disorders are common. We hypothesize that the comorbid anxiety results from an imbalance between the reward and antireward system due to persistent pain, which leads to the dysfunction of the pain and anxiety regulatory system. In this review, we will focus on changes in neuroplasticity, especially in neural circuits, during chronic pain and anxiety as observed in animal studies. Several neural circuits within specific regions of the brain, including the nucleus accumbens, lateral habenular, parabrachial nucleus, medial septum, anterior cingulate cortex, amygdala, hippocampus, medial prefrontal cortex, and bed nucleus of the stria terminalis, will be discussed based on novel findings after chemogenetic or optogenetic manipulation. We believe that these animal studies provide novel insights into human conditions and can guide clinical practice.
慢性疼痛患者常伴有精神障碍，焦虑障碍较为常见。我们假设，由于持续性疼痛导致奖赏和抗奖赏系统失衡，导致疼痛和焦虑调节系统功能障碍，从而引起共病性焦虑。在这篇综述中，我们将重点关注动物研究中观察到的慢性疼痛和焦虑期间神经可塑性的变化，特别是神经回路的变化。将根据化学遗传学或光遗传学操作后的新发现，讨论包括伏隔核、外侧缰核、臂旁核、中隔、前扣带皮层、杏仁核、海马、内侧前额叶皮层和终纹床核在内的大脑特定区域的几个神经回路。我们相信这些动物研究为人类疾病提供了新的见解，并可以指导临床实践。
