Denko C W
Agents Actions. 1978 Apr;8(3):268-79. doi: 10.1007/BF01966614.
Twenty patients with degenerative joint disease (DJD) of the hip were treated for prolonged periods with an extract of cartilage and bone marrow. Although clinical improvement, lessened joint pain and increased function, occurred in a majority of the patients, the most significant changes were in four who had concomitant x-ray improvement. These patients had roentgenographic evidence of recovery of joint space and regeneration of the femoral head. Discussion is presented of possible mechanisms by which this tissue extract induces changes in chondrocyte metabolism. A theory is proposed to explain DJD as a multifactorial disorder in which liver impairment in processing growth hormone is the key malfunction. Treatment of DJD of the hip by injections of the tissue extract of cartilage and bone marrow is a rational and effective therapy without significant toxicity.
二十名患有髋关节退行性关节病（DJD）的患者长期接受软骨和骨髓提取物治疗。尽管大多数患者出现了临床改善、关节疼痛减轻和功能增强的情况，但最显著的变化出现在四名同时有X线改善的患者身上。这些患者有影像学证据表明关节间隙恢复以及股骨头再生。文中讨论了这种组织提取物诱导软骨细胞代谢变化的可能机制。提出了一种理论来解释DJD是一种多因素疾病，其中肝脏在处理生长激素方面的损伤是关键故障。通过注射软骨和骨髓组织提取物治疗髋关节DJD是一种合理且有效的疗法，且无明显毒性。
