Denko C W, Gabriel P
Clin Rheumatol. 1983 Jun;2(2):115-22. doi: 10.1007/BF02032166.
New concepts of osteoarthritis (OA) are reviewed as preliminary to establishing a new classification of OA, defining sub-groups of OA based on combined biochemical and clinical data. The biochemical data are derived from assays of serum proteins--transferrin, ceruloplasmin, albumin, a1-acid glycoprotein, a1-antitrypsin, immunoglobulins A, G, and M. Standard clinical techniques are followed to provide clinical data, including medical history, physical examination, x-ray studies and routine biochemical tests. Genetic polymorphism is proposed as an explanation for subsets of OA. Extensive family history data is important in establishing connections.
作为建立骨关节炎（OA）新分类的前期工作，本文回顾了OA的新概念，即基于生化和临床综合数据定义OA的亚组。生化数据来自血清蛋白检测——转铁蛋白、铜蓝蛋白、白蛋白、α1-酸性糖蛋白、α1-抗胰蛋白酶、免疫球蛋白A、G和M。采用标准临床技术提供临床数据，包括病史、体格检查、X线检查和常规生化检测。提出基因多态性可作为OA亚组的一种解释。广泛的家族史数据对于建立联系很重要。
