Singh Urvashi, Singh Baljit, Bellini Maria Irene
Department of Surgery, Wythenshawe Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester M23 9LT, United Kingdom.
Department of Colorectal Surgery, University Hospitals Leicester, Leicester LE1 5WW, United Kingdom.
World J Transplant. 2022 Feb 18;12(2):21-23. doi: 10.5500/wjt.v12.i2.21.
Patients with inflammatory bowel disease (IBD) can develop extra-renal complications and as a result, suffer from end stage renal failure requiring kidney transplantation (KT). A brief review of available literature revealed that IBD patients undergoing KT have shorter overall survival rates compared to their controls. Literature reporting steroid regimens and survival outcomes specific to IBD and post kidney transplant are scarce and these studies have small sample sizes thus making it difficult to draw accurate conclusions. Further research is required in the form of a randomized controlled study to clarify the effect and mechanism of steroid immunosuppression on the prognosis of renal transplant recipients and explore new treatment schemes.
炎症性肠病（IBD）患者可能会出现肾外并发症，进而发展为终末期肾衰竭，需要进行肾移植（KT）。对现有文献的简要回顾显示，接受KT的IBD患者的总生存率低于对照组。关于IBD和肾移植后特定的类固醇方案及生存结果的文献较少，且这些研究样本量较小，因此难以得出准确结论。需要通过随机对照研究进一步开展研究，以阐明类固醇免疫抑制对肾移植受者预后的影响及机制，并探索新的治疗方案。
