Atkins Marvin D, Lumsden Alan B
Houston Methodist Hospital and Houston Methodist DeBakey Cardiovascular Surgery Associates, Houston, TX, USA.
Ann Cardiothorac Surg. 2022 Jan;11(1):16-25. doi: 10.21037/acs-2021-taes-171.
Aortic arch aneurysms are a challenging clinical problem especially in high-risk patients. Open aortic arch replacement, even in the best of centers, carries significant risk of stroke or death in this high-risk population. Many high-risk patients are deemed inoperable and not offered repair. Branched and fenestrated thoracic endografts are currently undergoing clinical trials in the United States but are not yet commercially available. Many elderly and frail patients have significant brachiocephalic occlusive disease or anatomy excluding them for consideration for such clinical trials. These patients also present with acute aortic syndromes requiring urgent or emergent repair and are unable to participate in clinical trials due to the time required to have such devices available. Alternative endovascular therapies, including parallel stent grafts (including Chimneys, Snorkels and Periscopes) and physician modified thoracic endografts, have been used to treat such high-risk patients combined with commercially available thoracic endovascular aneurysm repair (TEVAR) devices. This paper aims to review the techniques and current reported outcomes from parallel stent grafts and physician modified devices used to treat high risk patients undergoing repair for aortic arch pathologies.
主动脉弓动脉瘤是一个具有挑战性的临床问题,尤其是在高危患者中。即使在最好的医疗中心,开放性主动脉弓置换术在这类高危人群中也有发生中风或死亡的重大风险。许多高危患者被认为无法进行手术,因而未接受修复治疗。分支和开窗型胸主动脉腔内移植物目前正在美国进行临床试验,但尚未上市。许多老年体弱患者患有严重的头臂动脉闭塞性疾病或解剖结构不适合参与此类临床试验。这些患者还会出现需要紧急或急诊修复的急性主动脉综合征,并且由于获得此类装置所需的时间而无法参与临床试验。包括平行支架移植物(包括烟囱式、通气管式和潜望镜式)和医生改良型胸主动脉腔内移植物在内的替代性血管内治疗方法,已被用于联合使用市售胸主动脉腔内动脉瘤修复(TEVAR)装置治疗此类高危患者。本文旨在综述用于治疗因主动脉弓病变而接受修复的高危患者的平行支架移植物和医生改良型装置的技术及目前报道的治疗结果。