RNA m6A 修饰酶在染色质上的多功能作用。
Versatile functions of RNA m6A machinery on chromatin.
机构信息
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
J Mol Cell Biol. 2022 Jul 8;14(3). doi: 10.1093/jmcb/mjac011.
Abstract
m6A, a conserved and abundant modification on RNA, regulates RNA processing and function. RNA m6A machinery, including writers, erasers, and readers of m6A, is indispensable for m6A installation and function. Intriguingly, recent studies have revealed that m6A machinery can be recruited to chromatin by pleiotropic factors, including nascent RNA, transcription factors, regulatory RNA, histone modifications, and epigenetic machinery. Consequently, recruitment of m6A machinery can directly regulate chromatin biology, such as transcription, DNA damage repair, and DNA recombination beyond installation of m6A on nascent mRNA. Here, we discuss recent evidence showing that m6A machinery is targeted to chromatin and the direct biological consequences along with the underlying mechanisms.
摘要
m6A，一种在 RNA 上保守且丰富的修饰，调节 RNA 的加工和功能。RNA m6A 相关酶，包括 m6A 的写入酶、擦除酶和读取酶，对 m6A 的安装和功能是不可或缺的。有趣的是，最近的研究表明，m6A 相关酶可以通过多种因子（包括新生 RNA、转录因子、调节 RNA、组蛋白修饰和表观遗传酶）被招募到染色质上。因此，m6A 相关酶的招募可以直接调节染色质生物学，例如转录、DNA 损伤修复和 DNA 重组，而不仅仅是在新生 mRNA 上安装 m6A。在这里，我们讨论了最近的证据，表明 m6A 相关酶被靶向到染色质上，以及潜在的机制和直接的生物学后果。
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