Hu Kai-Lun, Chen Zimiao, Deng Wenhai, Li Xiaoxue, Ju Liping, Yang Haiyan, Zhang Hong, Mu Liangshan
Center for Reproductive Medicine, Peking University Third Hospital, No.49 Huayuan North Road, Haidian District, Beijing, People's Republic of China, 100191.
Zhejiang MedicalTech Therapeutics Company, No.665 Yumeng Road, Wenzhou, People's Republic of China, 325200.
Reprod Sci. 2022 Dec;29(12):3365-3372. doi: 10.1007/s43032-022-00856-8. Epub 2022 Feb 25.
The objective of this study is to investigate whether kisspeptin levels in early pregnancy have a better diagnostic value on early pregnancy outcome as compared with human chorionic gonadotropin (hCG). This study was a systematic review and meta-analysis aiming to investigate the diagnostic value of kisspeptin levels on early pregnancy outcome. The primary outcome was miscarriage or viable intrauterine pregnancy. Five studies were included for systematic review, and three studies were included for meta-analysis. Meta-analysis showed kisspeptin levels had a good diagnostic value with the area under the curve (AUC) 0.902 (0.866, 0.937) when kisspeptin was measured after 6 weeks of gestation. Sensitivity analysis demonstrated kisspeptin levels had a diagnostic value with AUC = 0.881 (0.855, 0.906). hCG levels had a diagnostic value with AUC = 0.834 (0.785, 0.883), which was inferior to the diagnostic value of kisspeptin (mean difference = 0.09 (0.02, 0.16)). Kisspeptin measurement has a potential for comparable or even higher accuracy than hCG in differentiating between miscarriage and viable intrauterine pregnancy after 6 weeks of gestation.
本研究的目的是调查与人类绒毛膜促性腺激素（hCG）相比，孕早期的 kisspeptin 水平对早期妊娠结局是否具有更好的诊断价值。本研究是一项系统评价和荟萃分析，旨在调查 kisspeptin 水平对早期妊娠结局的诊断价值。主要结局为流产或宫内活胎妊娠。纳入五项研究进行系统评价，三项研究进行荟萃分析。荟萃分析显示，在妊娠 6 周后测量 kisspeptin 时，其水平具有良好的诊断价值，曲线下面积（AUC）为 0.902（0.866，0.937）。敏感性分析表明 kisspeptin 水平的诊断价值为 AUC = 0.881（0.855，0.906）。hCG 水平的诊断价值为 AUC = 0.834（0.785，0.883），低于 kisspeptin 的诊断价值（平均差异 = 0.09（0.02，0.16））。在妊娠 6 周后区分流产和宫内活胎妊娠时，检测 kisspeptin 具有与 hCG 相当甚至更高的准确性的潜力。
