Ren Yixin, Chen Yongshou, Cao Shuang
Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Future Med Chem. 2022 Apr;14(8):571-586. doi: 10.4155/fmc-2021-0264. Epub 2022 Feb 25.
Influenza is a type of acute respiratory virus infection caused by the influenza virus that occurs in epidemics worldwide every year. Due to the increasing incidence of influenza virus resistance to existing drugs, researchers are looking for novel antiviral drugs with new mechanisms. The endonuclease activity of polymerase acidic protein is essential in the process of influenza virus reproduction, and inhibiting it could prevent the virus from replicating. There are relatively few drugs that act on this protein, and only baloxavir marboxil has been approved for clinical use. In this article, the structure and function of influenza virus polymerase acidic protein endonuclease, mechanism of action of polymerase acidic endonuclease inhibitors and the research progress of inhibitors are reviewed.
流感是一种由流感病毒引起的急性呼吸道病毒感染，每年在全球范围内流行。由于流感病毒对现有药物的耐药性发生率不断上升，研究人员正在寻找具有新作用机制的新型抗病毒药物。聚合酶酸性蛋白的核酸内切酶活性在流感病毒繁殖过程中至关重要，抑制它可以阻止病毒复制。作用于这种蛋白的药物相对较少，只有巴洛沙韦酯已被批准用于临床。本文综述了流感病毒聚合酶酸性蛋白核酸内切酶的结构与功能、聚合酶酸性核酸内切酶抑制剂的作用机制以及抑制剂的研究进展。
